Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.
Identifieur interne : 000752 ( Ncbi/Merge ); précédent : 000751; suivant : 000753Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.
Auteurs : K. Augustyns [Belgique] ; A. Van Aerschot ; A. Van Schepdael ; C. Urbanke ; P. HerdewijnSource :
- Nucleic acids research [ 0305-1048 ] ; 1991.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Adénine.
- métabolisme : Oligodésoxyribonucléotides, Polymères.
- synthèse chimique : Polymères.
- Adénine, Composition en bases nucléiques, Oligodésoxyribonucléotides, Stabilité enzymatique, Structure moléculaire, Température.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , chemical synthesis : Polymers.
- chemical , chemistry : Adenine, Oligodeoxyribonucleotides.
- chemical , metabolism : Oligodeoxyribonucleotides, Polymers.
- Base Composition, Enzyme Stability, Molecular Structure, Temperature.
Abstract
(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.
DOI: 10.1093/nar/19.10.2587
PubMed: 2041735
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pubmed:2041735Le document en format XML
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Van Schepdael</name></author><author><name sortKey="Urbanke, C" sort="Urbanke, C" uniqKey="Urbanke C" first="C" last="Urbanke">C. Urbanke</name></author><author><name sortKey="Herdewijn, P" sort="Herdewijn, P" uniqKey="Herdewijn P" first="P" last="Herdewijn">P. 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Herdewijn</name></author></analytic><series><title level="j">Nucleic acids research</title><idno type="ISSN">0305-1048</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenine (analogs & derivatives)</term><term>Adenine (chemistry)</term><term>Base Composition</term><term>Enzyme Stability</term><term>Molecular Structure</term><term>Oligodeoxyribonucleotides (chemistry)</term><term>Oligodeoxyribonucleotides (metabolism)</term><term>Polymers (chemical synthesis)</term><term>Polymers (metabolism)</term><term>Temperature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénine ()</term><term>Adénine (analogues et dérivés)</term><term>Composition en bases nucléiques</term><term>Oligodésoxyribonucléotides ()</term><term>Oligodésoxyribonucléotides (métabolisme)</term><term>Polymères (métabolisme)</term><term>Polymères (synthèse chimique)</term><term>Stabilité enzymatique</term><term>Structure moléculaire</term><term>Température</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Polymers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenine</term><term>Oligodeoxyribonucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oligodeoxyribonucleotides</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Oligodésoxyribonucléotides</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Polymères</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Composition</term><term>Enzyme Stability</term><term>Molecular Structure</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adénine</term><term>Composition en bases nucléiques</term><term>Oligodésoxyribonucléotides</term><term>Stabilité enzymatique</term><term>Structure moléculaire</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2041735</PMID><DateCompleted><Year>1991</Year><Month>07</Month><Day>11</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0305-1048</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>10</Issue><PubDate><Year>1991</Year><Month>May</Month><Day>25</Day></PubDate></JournalIssue><Title>Nucleic acids research</Title><ISOAbbreviation>Nucleic Acids Res.</ISOAbbreviation></Journal><ArticleTitle>Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.</ArticleTitle><Pagination><MedlinePgn>2587-93</MedlinePgn></Pagination><Abstract><AbstractText>(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Augustyns</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Rega Institute for Medical Research, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Aerschot</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Van Schepdael</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Urbanke</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Herdewijn</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucleic Acids Res</MedlineTA><NlmUniqueID>0411011</NlmUniqueID><ISSNLinking>0305-1048</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009838">Oligodeoxyribonucleotides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011108">Polymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>69926-59-6</RegistryNumber><NameOfSubstance UI="C069128">9-(3,4-dihydroxybutyl)adenine</NameOfSubstance></Chemical><Chemical><RegistryNumber>JAC85A2161</RegistryNumber><NameOfSubstance UI="D000225">Adenine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000225" MajorTopicYN="N">Adenine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001482" MajorTopicYN="N">Base Composition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004795" MajorTopicYN="N">Enzyme Stability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009838" MajorTopicYN="N">Oligodeoxyribonucleotides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011108" MajorTopicYN="N">Polymers</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013696" MajorTopicYN="N">Temperature</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>5</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>5</Month><Day>25</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>5</Month><Day>25</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2041735</ArticleId><ArticleId IdType="pmc">PMC328174</ArticleId><ArticleId IdType="doi">10.1093/nar/19.10.2587</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Am Chem Soc. 1973 Dec 26;95(26):8749-57</Citation><ArticleIdList><ArticleId IdType="pubmed">4783412</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1986 Jul 11;14(13):5399-407</Citation><ArticleIdList><ArticleId IdType="pubmed">3737406</ArticleId></ArticleIdList></Reference><Reference><Citation>Biotechniques. 1988 Sep;6(8):768-75</Citation><ArticleIdList><ArticleId IdType="pubmed">3273639</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1989 May 25;17(10):3735-45</Citation><ArticleIdList><ArticleId IdType="pubmed">2543953</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1988 Apr 25;16(8):3209-21</Citation><ArticleIdList><ArticleId IdType="pubmed">2836790</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li></country></list><tree><noCountry><name sortKey="Herdewijn, P" sort="Herdewijn, P" uniqKey="Herdewijn P" first="P" last="Herdewijn">P. Herdewijn</name><name sortKey="Urbanke, C" sort="Urbanke, C" uniqKey="Urbanke C" first="C" last="Urbanke">C. Urbanke</name><name sortKey="Van Aerschot, A" sort="Van Aerschot, A" uniqKey="Van Aerschot A" first="A" last="Van Aerschot">A. Van Aerschot</name><name sortKey="Van Schepdael, A" sort="Van Schepdael, A" uniqKey="Van Schepdael A" first="A" last="Van Schepdael">A. Van Schepdael</name></noCountry><country name="Belgique"><noRegion><name sortKey="Augustyns, K" sort="Augustyns, K" uniqKey="Augustyns K" first="K" last="Augustyns">K. Augustyns</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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